Nucleotide sequences of highly repeated DNAs; compilation and comments

Highly repeated sequences in mammalian genomes.

Histone Sequence Database: a compilation of highly-conserved nucleoprotein sequences

By searching the current protein sequence databases using sequences from human and chicken histones H1/H5, H2A, H2B, H3 and H4, a database of aligned histone protein sequences with statistically significant sequence similarity to the search sequence was constructed. In addition, a nucleotide sequence database of the corresponding coding regions for these proteins has been assembled. The region ...

Compilation of tRNA sequences

This compilation presents in a small space the tRNA sequences so far published. The numbering of tRNAPhe from yeast is used following the rules proposed by the participants of the Cold Spring Harbor Meeting on tRNA 1978 (1,2;Fig. 1). This numbering allows comparisons with the three dimensional structure of tRNAPhe. The secondary structure of tRNAs is indicated by specific underlining. In the pr...

Homogenization of tandemly repeated nucleotide sequences by distance-dependent nucleotide sequence conversion.

Previous work revealed that recurrent mutations (= mutation occurring more than once) in the tandemly repeated arrays present in nontranscribed spacers (NTS) of ribosomal RNA genes (rDNA) are clustered, i.e., they most frequently occur in repeats with adjacent or alternate distribution. A possible explanation is that the likelihood of heteroduplex formation, a prerequisite of gene conversion, d...

Those mysterious sequences of satellite DNAs

Since the early beginnings of understanding the genome structure, it has been realized that highly abundant, noncoding DNA sequences repeated in tandem, satellite DNAs, compose significant portions of every eukaryotic genome (1, 2). Satellite DNAs are located in heterochromatic chromosomal regions usually formed around centromeres and at chromosome termini at interstitial positions. Little is k...